Palmitic Acid: Physiological Role, Metabolism and Nutritional Implications

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Palmitic Acid: Physiological Role, Metabolism and Nutritional Implications

Palmitic acid (PA) has been for long time negatively depicted for its putative detrimental health effects, shadowing its multiple crucial physiological activities. PA is the most common saturated fatty acid accounting for 20-30% of total fatty acids in the human body and can be provided in the diet or synthesized endogenously via de novo lipogenesis (DNL). PA tissue content seems to be controll...

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Effects of fasting and pyruvate on palmitic acid metabolism.

Neither fasting nor pyruvate supplementation affects the oxidation of octanoic acid by liver slices (l-3). Similarly, neither fasting nor glucose supplementation affects the oxidation of this acid by the intact rat (4). On the other hand, the oxidation in vivo of palmitic acid and tripalmitin is increased by prior fasting of the animal and decreased by prior glucose administration (4). The diff...

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Metabolism of Palmitic Acid in Perfused Rat Heart.

EVANS, JOHN R., LIONEL H. OPIE, AND JOSEPH C. SHIPP. Metabolism of palmitic acid in perfused rat heart. Am. J. Fhysiol. 205(4): 766-770. I g63,-Metabolism of fatty acid was studied in the isolated rat heart perfused with albumin-bound palmitate-C 14. Uptake of fatty acid by the heart was related to the concentration of fatty acid present and the molar ratio of fatty acid to albumin in the perfu...

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Palmitic acid and linoleic acid metabolism in Caco-2 cells: different triglyceride synthesis and lipoprotein secretion.

Polarized monolayers of intestinal Caco-2 cells were used to study the effects of saturated palmitic acid (16:0) and polyunsaturated linoleic acid (18:2) on triglyceride synthesis and lipoprotein secretion. Monolayers were incubated for 24 h, at the apical or lumenal side, with palmitic acid (16:0) or linoleic acid (18:2) in physiological concentrations. Incubation with 1.0 mM 16:0 or 18:2 resu...

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Alpha-linolenic acid metabolism in men and women: nutritional and biological implications.

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ژورنال

عنوان ژورنال: Frontiers in Physiology

سال: 2017

ISSN: 1664-042X

DOI: 10.3389/fphys.2017.00902